Content, progress and pedagogy of the module

This course provides an in-depth understanding of recovery and purification (downstream processing) strategies for chemical and biological products. The course covers key separation principles, various technologies, process design considerations, and the integration of upstream and downstream operations.

Learning objectives

Knowledge

Students who complete the module must be able to

• account for industrial downstream processing methods for different types of products
• describe the main principles of process design and development of downstream processing strategies
• explain the impact of fermentation or upstream process characteristics on downstream processing
• account for fundamental separation principles and assess their effectiveness in different process contexts.
• account for product release, secretion, cell disruption, flocculation processes, centrifugation, conventional filtration and membrane filtration, precipitation processes, process chromatography, product polishing, and distillation.

Skills

• calculate sizing and scale up of most frequently used unit operations in real application
• develop complete downstream processing workflows for different types of chemical and biological products, integrating multiple unit operations.
• Analyze, compare, and select appropriate separation and purification methods based on process requirements, product properties, and sustainability considerations.

Type of instruction

• Lectures
• Workshops
• Exercises

Extent and expected workload

150 hours

Exam

Exams